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4 months ago
Human form of 'mad cow' disease may spread through touch

New Delhi: The lethal Creutzfeldt-Jakob disease, the human form of the 'mad cow' disease, may spread through touch, say scientists.

An abnormal protein linked to the fatal infection can be detected from the skin of patients.

Scientists from National Institutes of Health and Case Western Reserve University in the US have detected abnormal prion protein in the skin of nearly two dozen people who died from Creutzfeldt-Jakob disease (CJD).

The scientists also exposed a dozen healthy mice to skin extracts from two of the CJD patients, and all developed prion disease.

The study, published in the journal Science Translational Medicine, raise questions about the possible transmissibility of prion diseases via medical procedures involving skin, and whether skin samples might be used to detect prion disease.

Researchers from NIH's National Institute of Allergy and Infectious Diseases (NIAID) stress that the prion-seeding potential found in skin tissue is significantly less than what they have found in studies using brain tissue.

CJD is an incurable and ultimately fatal transmissible, neurodegenerative disorder in the family of prion diseases.

Prion diseases originate when normally harmless prion protein molecules become abnormal and gather in clusters and filaments in the human body and brain.

The reasons for this process are not fully understood. The accumulation of these clusters has been associated with tissue damage that leaves sponge-like holes in the brain.

Human prion diseases include fatal insomnia; kuru; Gerstmann-Straussler-Scheinker syndrome; and variant, familial and sporadic CJD.

Sporadic CJD is the most common human prion disease, affecting about one in one million people annually worldwide.

Other prion diseases include scrapie in sheep; chronic wasting disease in deer, elk and moose; and bovine spongiform encephalopathy, or mad cow disease, in cattle.

Most people associate prion diseases with the brain, although scientists have found abnormal infectious prion protein in other organs, including the spleen, kidney, lungs and liver.

(With Agency inputs)

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